I'm making a game in Picotron, specifically a remake (or demake depending on how you see it) of Puyo Puyo. I'm basing it off the MSX2 version, and was wondering:
a. Is it possible to specify your own custom resolution for a cart?
b. If so, how would I do that?

I want the game to run at 256x192 pixels, the native resolution of the MSX.

The title screen of Puyo Puyo MSX, for reference.

Thanks for reading! ^_^

According to the documentation…
https://www.lexaloffle.com/dl/docs/picotron_manual.html#vid

vid(0) -- 480x270
vid(3) -- 240x135
vid(4) -- 160x90

In the future, support may expand, as the roadmap lists "support for additional fullscreen video modes," but implementations of video modes with different aspect ratios are not pixel-perfect and may not become widespread.

Like sugarflower mentioned, only the specified video resolutions are available.
However, the "clip" and/or "camera" functions may be of interest to you if you wish to stimulate that screen resolution in drawing!

I think within Picotron that you may be able to set custom window dimensions but these would only apply to the in-environment windows created! Picotron, as an application in your host OS, would still occupy one of those mentioned screen resolutions I think.

You could also draw to a 256x192 userdata, and then blit or sspr that to the screen.