I've noticed that after few hours of using Pico, it starts to get more and more memory, but only when you start opening many different carts in a single, long (few hours, the shortest time I've seen it happening was in a session about 3h long) session. Obviously closing and reopening pico fixes it, but it should be looked into even if it's small (the biggest it got in memory was about 450MB when leaking).

//edit: Also the first sign the leak is happening is that sound starts to get choppy. That was what alerted me of the issue for the first time and I was investigating it for the past 3 days to get to what exactly causes it.

which version of pico8 were you using, and on which platform?