https://www.hardkernel.com/main/products/prdt_info.php?g_code=G152875062626
Odroid just released this new product. I'm to noob to understand how, but since it can run game boy it could run pico-8, or am I missing something?

Looks like an interesting little package, but there's one flaw for running PICO-8 stuff: the LCD resolution.

The LCD is 320x240, so you either run 128x128 PICO-8 1:1 as a postage stamp in the middle, 2:1 with the top and bottom cut off, or scaled to fit with either uneven or blurry pixels.

I wonder if it would handle a different screen gracefully...

I mean it seems like a glorified Arduino board, so I don't see why with some fiddling you couldn't use a different display. Admittedly, I didn't look into it very much.